Hair loss
Ketoconazole shampoo in conjunction with an oral 5α-reductase inhibitor has been used off label to treat and rogenic alopecia.
The antifungal properties of ketoconazole reduce scalp microflora and consequently may reduce follicular inflammation that contributes to alopecia.Limited clinical studies suggest ketoconazole shampoo used either alone or in combination with other treatments may be useful in reducing hair loss. At least one study has been performed showing that ketoconazole may be useful in temporarily reducing erectile function in postoperative penile surgery patients.
Veterinary use
Ketoconazole Cas 65277-42-1 is also sometimes prescribed by veterinarians for use on pets, often as unflavored tablets that may need to be cut to smaller size for correct dosage.
Ketoconazole is usually prescribed for fungal infections of the skin and mucous membranes, such as athlete's foot, ringworm, candidiasis (yeast infection or thrush), jock itch, and tinea versicolor.
Topical ketoconazole Cas 65277-42-1 is also used as a treatment for dandruff (seborrheic dermatitis of the scalp) and for seborrheic dermatitis on other areas of the body, perhaps acting in these conditions by suppressing levels of the fungus Malassezia furfur on the skin.
| Items | Specification | Results |
| Characters | Almost white power | Almost white power |
| Identification | Positive | Positive |
| Appearance of solution | Solution S should be clear and not more intensely | Complies |
| Solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in methanol, sparingly soluble in alcohol. |
Complies |
| Specific optical rotation | Between-0.10° and +0.10° | 0.001° |
| Related substances | ≤0.5% | 0.16% |
| Heavy metals | ≤20ppm | ＜20ppm |
| Loss on drying | ≤0.5% | 0.06% |
| Sulphated ash | ≤0.1% | 0.04% |
| Assay | 99.0%～101.0% | 99.9% |
| Total Aerobic Microbial Count | ≤102cfu/g | Qualified |
| Total Yeasts and Molds Count | ≤10'cfu/g | Qualified |
| Pseudomonas aeruginosa | Absent per g | Qualified |
| Staphylococcus aureus | Absent per g | Qualified |
| Conclusion | The quality of the above commodity complies standard of BP/EP | |
| Packaging and storage | Preserve in well-closed containers, protected from light for 48 months. | |
